Allergic diseases among Asian children in the United States.
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ABSTRACT:
SUBMITTER: Dunlop JH
PROVIDER: S-EPMC8456364 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Allergic diseases among Asian children in the United States.
Dunlop Joan H JH Keet Corinne A CA
The Journal of allergy and clinical immunology 20190823 6
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Project description:Higher concentrations of heavy metals were reported mainly among adult Asian persons compared to other racial/ethnic groups in earlier NHANES cycles' studies. We aimed to examine concentrations of metals among Asian children/adolescents compared to children/adolescents identifying with other racial/ethnic groups, considering socio-demographic factors and potential mediation by fish/shellfish consumption. Using NHANES data (2015-2018), 5293 participants (1-19 years) with blood/urinary measurements of lead, cadmium, mercury and arsenic were included. Survey-weighted adjusted generalized linear models assessed differences in log-transformed metal concentrations between Asian and non-Asian participants, considering potential effect measure modification by parental education. Causal mediation effects of recent fish/shellfish consumption were estimated. Log-transformed metal concentrations were higher among Asian than among non-Asian children/adolescents. Lower parental education was associated with higher concentrations of cadmium and methylmercury among Asian participants, and effect measure modification was suggested. Proportions of the mercury exposure disparity mediated by recent fish/shellfish consumption were 9.1% (95% CI 2.6, 17.3%) for fish, and 5.7% (0.5, 12.0%) for shellfish, with similar findings for methylmercury. Overall, Asian identification was associated with higher toxic metal exposure, and among Asian children/adolescents those with parents with lower education were particularly affected. Dietary fish/shellfish intake explained a portion of the disparities. Prevention efforts should identify sources of elevated metal exposure focusing children and adolescents while considering diverse backgrounds and dietary habits including high fish consumption.
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Project description:ObjectiveTo examine experiences of racial discrimination among Asian Americans, which broadly contribute to poor health outcomes.Data source and study designData come from a nationally representative, probability-based telephone survey, including 500 Asian and a comparison group of 902 white US adults, conducted January to April 2017.MethodsWe calculated the percent of Asian Americans reporting discrimination in several domains, including health care. We used logistic regression to compare the Asian-white difference in odds of discrimination, and among Asians only to examine variation by geographic heritage group (South Asian versus East Asian) and gender.Principal findings13 percent of Asians reported discrimination in healthcare encounters. At least one in four adults reported experiencing discrimination in employment (27 percent job applications, 25 percent equal pay/promotions); housing (25 percent); and interpersonal interactions (35 percent microaggressions, 32 percent racial slurs). In unadjusted models, East and South Asians were more likely than whites to report experiences of institutional discrimination, and South Asians were more likely than whites to report microaggressions. In adjusted models, Asians had higher odds than whites of reporting avoiding health care due to discrimination concerns and also when obtaining housing.ConclusionsAsians in the United States experience discrimination interpersonally and across many institutional settings, including housing and health care. South Asians may be especially vulnerable to forms of institutional discrimination and microaggressions. These results illustrate a need for greater investigation into the unique experiences of Asian subgroups and greater protections for groups at higher risk of discrimination, within health care and beyond.
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Project description:DNA methylation alteration marks phthlate mediated transgenerational inheritance in murine allergic diseases.
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