White matter hyperintensities and cognition across different Alzheimer's biomarker profiles.

ABSTRACT:

Background/objectives

To examine the association between white matter hyperintensities (WMH) and cognitive domains such as memory and executive function (EF) across different clinical and biomarker categories of Alzheimer's disease (AD).

Design

Cross-sectional study.

Setting

Alzheimer's Disease Neuroimaging Initiative.

Participants

A total of 216 cognitively normal (CN) participants and 407 participants with mild cognitive impairment (MCI) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) at baseline.

Measurements

Based on the 2018 research framework, participants were classified using AT(N) (amyloid-β deposition [A], pathologic tau [T], and neurodegeneration [(N)]) biomarkers into one of three categories: biomarker negative [A - T- (N)-], amyl

SUBMITTER: Lam S 

PROVIDER: S-EPMC8456365 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature