Mutational sources of trans-regulatory variation affecting gene expression in Saccharomyces cerevisiae.

ABSTRACT: Heritable variation in a gene's expression arises from mutations impacting cis- and trans-acting components of its regulatory network. Here, we investigate how trans-regulatory mutations are distributed within the genome and within a gene regulatory network by identifying and characterizing 69 mutations with trans-regulatory effects on expression of the same focal gene in Saccharomyces cerevisiae. Relative to 1766 mutations without effects on expression of this focal gene, we found that these trans-regulatory mutations were enriched in coding sequences of transcription factors previously predicted to regulate expression of the focal gene. However, over 90% of the trans-regulatory mutations identified mapped to other types of genes involved i

SUBMITTER: Duveau F 

PROVIDER: S-EPMC8456550 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature