Image-guided selection of Gd@C-dots as sensitizers to improve radiotherapy of non-small cell lung cancer.

ABSTRACT:

Background

Recently, gadolinium-intercalated carbon dots (Gd@C-dots) have demonstrated potential advantages over traditional high-Z nanoparticles (HZNPs) as radiosensitizers due to their high stability, minimal metal leakage, and remarkable efficacy.

Results

In this work, two Gd@C-dots formulations were fabricated which bore carboxylic acid (CA-Gd@C-dots) or amino group (pPD-Gd@C-dots), respectively, on the carbon shell. While it is critical to develop innovative nanomateirals for cancer therapy, determining their tumor accumulation and retention is equally important. Therefore, in vivo positron emission tomography (PET) was performed, which found that ⁶⁴Cu-labeled pPD-Gd@C-dots demonstrated significantly improved tumor retention (up to 48 h post injection) compar

SUBMITTER: Ma X 

PROVIDER: S-EPMC8456633 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature