HA-coated collagen nanofibers for urethral regeneration via in situ polarization of M2 macrophages.

ABSTRACT: In situ tissue engineering utilizes the regenerative potential of the human body to control cell function for tissue regeneration and has shown considerable prospect in urology. However, many problems are still to be understood, especially the interactions between scaffolds and host macrophages at the wound site and how these interactions direct tissue integration and regeneration. This study was designed to evaluate the efficacy of hyaluronic acid (HA) functionalized collagen nanofibers in modulating the pro-healing phenotype expression of macrophages for urethral regeneration. Tubular HA-collagen nanofibers with HA-coating were prepared by coaxial electrospinning. The formation of a thin HA-coating atop each collagen nanofiber endowed its nanofibrous mats with higher anisotropic wettabil

SUBMITTER: Niu Y 

PROVIDER: S-EPMC8456673 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature