Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development.

ABSTRACT: Human hematopoiesis is a dynamic process that starts in utero 18-21 days post-conception. Understanding the site- and stage-specific variation in hematopoiesis is important if we are to understand the origin of hematological disorders, many of which occur at specific points in the human lifespan. To unravel how the hematopoietic stem/progenitor cell (HSPC) compartment changes during human ontogeny and the underlying gene regulatory mechanisms, we compare 57,489 HSPCs from 5 different tissues spanning 4 developmental stages through the human lifetime. Single-cell transcriptomic analysis identifies significant site- and developmental stage-specific transitions in cellular architecture and gene regulatory networks. Hematopoietic stem cells show progression from cycling to quiescence and incre

SUBMITTER: Roy A 

PROVIDER: S-EPMC8456780 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature