Dynamic Catalytic Highly Enantioselective 1,3-Dipolar Cycloadditions.

ABSTRACT: In dynamic covalent chemistry, reactions follow a thermodynamically controlled pathway through equilibria. Reversible covalent-bond formation and breaking in a dynamic process enables the interconversion of products formed under kinetic control to thermodynamically more stable isomers. Notably, enantioselective catalysis of dynamic transformations has not been reported and applied in complex molecule synthesis. We describe the discovery of dynamic covalent enantioselective metal-complex-catalyzed 1,3-dipolar cycloaddition reactions. We have developed a stereodivergent tandem synthesis of structurally and stereochemically complex molecules that generates eight stereocenters with high diastereo- and enantioselectivity through asymmetric reversible bond formation in a dynamic process in two c

SUBMITTER: Yildirim O 

PROVIDER: S-EPMC8456807 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature