Treatment planning and 4D robust evaluation strategy for proton therapy of lung tumors with large motion amplitude.

ABSTRACT:

Purpose

Intensity-modulated proton therapy (IMPT) for lung tumors with a large tumor movement is challenging due to loss of robustness in the target coverage. Often an upper cut-off at 5-mm tumor movement is used for proton patient selection. In this study, we propose (1) a robust and easily implementable treatment planning strategy for lung tumors with a movement larger than 5 mm, and (2) a four-dimensional computed tomography (4DCT) robust evaluation strategy for evaluating the dose distribution on the breathing phases.

Materials and methods

We created a treatment planning strategy based on the internal target volume (ITV) concept (aim 1). The ITV was created as a union of the clinical target volumes (CTVs) on the eight 4DCT phases. The ITV expanded by 2 mm was the target

SUBMITTER: Taasti VT 

PROVIDER: S-EPMC8456954 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature