Comprehensive assessment of side effects associated with a single dose of ketamine in treatment-resistant depression.

ABSTRACT:

Background

Concerns about ketamine for treating depression include abuse potential and the occurrence of psychotomimetic effects. This study sought to comprehensively assess side effects (SEs) associated with a single subanesthetic-dose intravenous ketamine infusion. A secondary aim was to examine the relationship between Clinician-Administered Dissociative States Scale (CADSS) scores and dissociative symptoms reported on a comprehensive, clinician-administered SE questionnaire.

Methods

Data from 188 participants were pooled from four placebo-controlled, crossover ketamine trials and one open-label study (n = 163 with either treatment-resistant major depressive disorder or bipolar disorder and 25 healthy controls). SEs were actively solicited in a standardized fashion and mo

SUBMITTER: Acevedo-Diaz EE 

PROVIDER: S-EPMC8457026 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature