Use of metformin to prolong gestation in preterm pre-eclampsia: randomised, double blind, placebo controlled trial.

ABSTRACT:

Objective

To evaluate whether extended release metformin could be used to prolong gestation in women being expectantly managed for preterm pre-eclampsia.

Design

Randomised, double blind, placebo controlled trial.

Setting

Referral hospital in Cape Town, South Africa.

Participants

180 women with preterm pre-eclampsia between 26+0 to 31+6 weeks' gestation undergoing expectant management: 90 were randomised to extended release metformin and 90 to placebo.

Intervention

3 g of oral extended release metformin or placebo daily, in divided doses, until delivery.

Main outcome measure

The primary outcome was prolongation of gestation.

Results

Of 180 participants, one woman delivered before taking any trial drug. The median time from randomisation to d

SUBMITTER: Cluver CA 

PROVIDER: S-EPMC8457042 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature