Characterizing the Genetic Architecture of Parkinson's Disease in Latinos.

ABSTRACT:

Objective

This work was undertaken in order to identify Parkinson's disease (PD) risk variants in a Latino cohort, to describe the overlap in the genetic architecture of PD in Latinos compared to European-ancestry subjects, and to increase the diversity in PD genome-wide association (GWAS) data.

Methods

We genotyped and imputed 1,497 PD cases and controls recruited from nine clinical sites across South America. We performed a GWAS using logistic mixed models; variants with a p-value <1 × 10^-5 were tested in a replication cohort of 1,234 self-reported Latino PD cases and 439,522 Latino controls from 23andMe, Inc. We also performed an admixture mapping analysis where local ancestry blocks were tested for association with PD status.

Results

One locus, SNCA, ac

SUBMITTER: Loesch DP 

PROVIDER: S-EPMC8457043 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature