An Evidence-Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine.

ABSTRACT: Clinical annotations are one of the most popular resources available on the Pharmacogenomics Knowledgebase (PharmGKB). Each clinical annotation summarizes the association between variant-drug pairs, shows relevant findings from the curated literature, and is assigned a level of evidence (LOE) to indicate the strength of support for that association. Evidence from the pharmacogenomic literature is curated into PharmGKB as variant annotations, which can be used to create new clinical annotations or added to existing clinical annotations. This means that the same clinical annotation can be worked on by multiple curators over time. As more evidence is curated into PharmGKB, the task of maintaining consistency when assessing all the available evidence and assigning an LOE becomes increasingly d

SUBMITTER: Whirl-Carrillo M 

PROVIDER: S-EPMC8457105 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature