Normal human brainstem development in vivo: a quantitative fetal MRI study.

ABSTRACT:

Objectives

To characterize spatiotemporal growth differences of prenatal brainstem substructures and cerebellum, using linear biometry and planimetry on fetal magnetic resonance imaging (MRI).

Methods

In this retrospective study, we included fetuses with normal brain and a precise midsagittal T2-weighted brain MRI sequence obtained between May 2003 and April 2019. The cross-sectional area, rostrocaudal diameter and anteroposterior diameter of the midbrain, pons (basis pontis and pontine tegmentum), medulla oblongata and cerebellar vermis, as well as the transverse cerebellar diameter, were quantified by a single observer. The diameters were also assessed by a second observer to test inter-rater variability.

Results

We included 161 fetuses with normal brain and a preci

SUBMITTER: Dovjak GO 

PROVIDER: S-EPMC8457244 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature