Computed Tomography-Based Assessment of Transvalvular Pressure Gradient in Aortic Stenosis.

ABSTRACT: Background: In patients with aortic stenosis, computed tomography (CT) provides important information about cardiovascular anatomy for treatment planning but is limited in determining relevant hemodynamic parameters such as the transvalvular pressure gradient (TPG). Purpose: In the present study, we aimed to validate a reduced-order model method for assessing TPG in aortic stenosis using CT data. Methods: TPG_CT was calculated using a reduced-order model requiring the patient-specific peak-systolic aortic flow rate (Q) and the aortic valve area (AVA). AVA was determined by segmentation of the aortic valve leaflets, whereas Q was quantified based on volumetric assessment of the left ventricle. For validation, invasively measured TPG_catheter was calc

SUBMITTER: Franke B 

PROVIDER: S-EPMC8457381 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature