Trifluoromethyl substitution enhances photoinduced activity against breast cancer cells but reduces ligand exchange in Ru(ii) complex.

ABSTRACT: A series of five ruthenium complexes containing triphenyl phosphine groups known to enhance both cellular penetration and photoinduced ligand exchange, cis-[Ru(bpy)₂(P(p-R-Ph)₃)(CH₃CN)]²⁺, where bpy = 2,2'-bipyridine and P(p-R-Ph)₃ represent para-substituted triphenylphosphine ligands with R = -OCH₃ (1), -CH₃ (2) -H (3), -F (4), and -CF₃ (5), were synthesized and characterized. The photolysis of 1-5 in water with visible light (λ _irr ≥ 395 nm) results in the substitution of the coordinated acetonitrile with a solvent molecule, generating the corresponding aqua complex as the single photoproduct. A 3-fold variation in

SUBMITTER: Lanquist AP 

PROVIDER: S-EPMC8457392 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature