Chromosomal neighbourhoods allow identification of organ specific changes in gene expression.

ABSTRACT: Although most genes share their chromosomal neighbourhood with other genes, distribution of genes has not been explored in the context of individual organ development; the common focus of developmental biology studies. Because developmental processes are often associated with initially subtle changes in gene expression, here we explored whether neighbouring genes are informative in the identification of differentially expressed genes. First, we quantified the chromosomal neighbourhood patterns of genes having related functional roles in the mammalian genome. Although the majority of protein coding genes have at least five neighbours within 1 Mb window around each gene, very few of these neighbours regulate development of the same organ. Analyses of transcriptomes of developing mouse molar

SUBMITTER: Das Roy R 

PROVIDER: S-EPMC8457456 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature