Development and Validation of a ¹⁸F-FDG PET-Based Radiomic Model for Evaluating Hypermetabolic Mediastinal-Hilar Lymph Nodes in Non-Small-Cell Lung Cancer.

ABSTRACT:

Background

Accurate evaluation of lymph node (LN) status is critical for determining the treatment options in patients with non-small cell lung cancer (NSCLC). This study aimed to develop and validate a ¹⁸F-FDG PET-based radiomic model for the identification of metastatic LNs from the hypermetabolic mediastinal-hilar LNs in NSCLC.

Methods

We retrospectively reviewed 259 patients with hypermetabolic LNs who underwent pretreatment ¹⁸F-FDG PET/CT and were pathologically confirmed as NSCLC from two centers. Two hundred twenty-eight LNs were allocated to a training cohort (LN = 159) and an internal validation cohort (LN = 69) from one center (7:3 ratio), and 60 LNs were enrolled to an external validation cohort from the other. Radiomic features were extracte

SUBMITTER: Ouyang ML 

PROVIDER: S-EPMC8457532 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature