Familial longevity is associated with lower baseline bone turnover but not differences in bone turnover in response to rhTSH.

ABSTRACT:

Context

Offspring from long-lived families have a different thyroid status than controls, characterised by higher circulating levels of thyroid stimulating hormone (TSH) and similar levels of thyroid hormone. Expression of the TSH receptor has previously been observed on various extrathyroidal tissues, including bone. However, potential physiological consequences of differences in circulating TSH as observed in familial longevity on bone tissue remain unclear.

Objective

Based on the hypothesis that TSH may inhibit bone resorption, we explored whether offspring of long-lived families have lower bone turnover than controls at baseline as well as following a challenge with recombinant human TSH (rhTSH).

Methods

Bone turnover markers CTX and P1NP were measured in fasted m

SUBMITTER: Zutinic A 

PROVIDER: S-EPMC8457556 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature