Knock-down of odr-3 and ife-2 additively extends lifespan and healthspan in C. elegans.

ABSTRACT: Genetic manipulations can ameliorate the aging process and extend the lifespan of model organisms. The aim of this research was to identify novel genetic interventions that promote both lifespan and healthspan, by combining the effects of multiple longevity-associated gene inactivations in C. elegans. For this, the individual and combined effects of the odr-3 mutation and of ife-2 and cku-70 knock-downs were studied, both in the wild type and daf-16 mutant backgrounds. We found that besides increasing the lifespan of wild type animals, the knock-down of ife-2 (starting at L4) also extends the lifespan and healthspan of long-lived odr-3 mutants. In the daf-16 background, ife-2 and odr-3 impairment exert opposing effects i

SUBMITTER: Matei IV 

PROVIDER: S-EPMC8457566 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature