Calorie intake rather than food quantity consumed is the key factor for the anti-aging effect of calorie restriction.

ABSTRACT: Although calorie restriction has been reported to extend lifespan in several organisms, animals subjected to calorie restriction consume not only fewer calories but also smaller quantities of food. Whether it is the overall restriction of calories or the coincidental reduction in the quantity of food consumed that mediates the anti-aging effects is unclear. Here, we subjected mice to five dietary interventions. We showed that both calorie and quantity restriction could improve early survival, but no maximum lifespan extension was observed in the mice fed isocaloric diet in which food quantity was reduced. Mice fed isoquant diet with fewer calories showed maximum lifespan extension and improved health among all the groups, suggesting that calorie intake rather than food quantity consumed is

SUBMITTER: Liang Y 

PROVIDER: S-EPMC8457579 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature