M⁶A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression.

ABSTRACT: Esophageal squamous cell carcinoma (ESCC) is a highly malignant gastrointestinal cancer with a high recurrence rate and poor prognosis. Although N⁶-methyladenosine (m⁶A), the most abundant epitranscriptomic modification of mRNAs, has been implicated in several cancers, little is known about its participation in ESCC progression. We found reduced expression of ALKBH5, an m⁶A demethylase, in ESCC tissue specimens with a more pronounced effect in T3-T4, N1-N3, clinical stages III-IV, and histological grade III tumors, suggesting its involvement in advanced stages of ESCC. Exogenous expression of ALKBH5 inhibited the in vitro proliferation of ESCC cells, whereas depletion of endogenous ALKBH5 markedly enhanced ESCC cell proliferation in vitro. Thi

SUBMITTER: Xiao D 

PROVIDER: S-EPMC8457604 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature