Ontology highlight
ABSTRACT:
SUBMITTER: Becht E
PROVIDER: S-EPMC8457665 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Becht Etienne E Tolstrup Daniel D Dutertre Charles-Antoine CA Morawski Peter A PA Campbell Daniel J DJ Ginhoux Florent F Newell Evan W EW Gottardo Raphael R Headley Mark B MB
Science advances 20210922 39
Modern immunologic research increasingly requires high-dimensional analyses to understand the complex milieu of cell types that comprise the tissue microenvironments of disease. To achieve this, we developed Infinity Flow combining hundreds of overlapping flow cytometry panels using machine learning to enable the simultaneous analysis of the coexpression patterns of hundreds of surface-expressed proteins across millions of individual cells. In this study, we demonstrate that this approach allows ...[more]