Metabolite patterns link diet, obesity, and type 2 diabetes in a Hispanic population.

ABSTRACT:

Introduction

Obesity is a precursor of type 2 diabetes (T2D).

Objectives

Our aim was to identify metabolic signatures of T2D and dietary factors unique to obesity.

Methods

We examined a subsample of the Boston Puerto Rican Health Study (BPRHS) population with a high prevalence of obesity and T2D at baseline (n = 806) and participants (without T2D at baseline) at 5-year follow-up (n = 412). We determined differences in metabolite profiles between T2D and non-T2D participants of the whole sample and according to abdominal obesity status. Enrichment analysis was performed to identify metabolic pathways that were over-represented by metabolites that differed between T2D and non-T2D participants. T2D-associated metabolites unique to obesity were examined for correlation wi

SUBMITTER: Parnell LD 

PROVIDER: S-EPMC8458177 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature