Dataset Information
Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
Ontology highlight
ABSTRACT:
SUBMITTER: Velagapudi S
PROVIDER: S-EPMC8458249 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
Arteriosclerosis, thrombosis, and vascular biology 20210819 10
Objective: ApoM enriches S1P (sphingosine-1-phosphate) within HDL (high-density lipoproteins) and facilitates the activation of the S1P1 (S1P receptor type 1) by S1P, thereby preserving endothelial barrier function. Many protective functions exerted by HDL in extravascular tissues raise the question of how S1P regulates transendothelial HDL transport. Approach and Results: HDL were isolated from plasma of wild-type mice, Apom knockout mice, human apoM transgenic mice or humans and radioiodinate ...[more]
