Single-cell profiling defines the prognostic benefit of CD39^high tissue resident memory CD8+ T cells in luminal-like breast cancer.

ABSTRACT: Luminal-like breast cancer (BC) constitutes the majority of BC subtypes, but, differently from highly aggressive triple negative BC, is poorly infiltrated by the immune system. The quality of the immune infiltrate in luminal-like BCs has been poorly studied, thereby limiting further investigation of immunotherapeutic strategies. By using high-dimensional single-cell technologies, we identify heterogeneous behavior within the tissue-resident memory CD8+ T (Trm) cells infiltrating luminal-like tumors. A subset of CD127- CD39^hi Trm cells, preferentially present in the tumor compared to the adjacent normal breast tissue or peripheral blood, retains enhanced degranulation capacity compared to the CD127+ CD39^lo Trm counterpart ex vivo, and is specifically associated with po

SUBMITTER: Losurdo A 

PROVIDER: S-EPMC8458450 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature