Adaptation and early implementation of the PREdiction model for gene mutations (PREMM₅™) for lynch syndrome risk assessment in a diverse population.

ABSTRACT: Lynch syndrome (LS) is the most common inherited cause of colorectal and endometrial cancers. Identifying individuals at risk for LS without personal cancer history requires detailed collection and assessment of family health history. However, barriers exist to family health history collection, especially in historically underserved populations. To improve LS risk assessment in historically underserved populations, we adapted the provider-facing PREdiction Model for gene Mutations (PREMM₅™ model), a validated LS risk assessment model, into a patient-facing electronic application through an iterative development process involving expert and patient stakeholders. We report on preliminary findings based on the first 500 individuals exposed to the adapted application in a primary ca

SUBMITTER: Mittendorf KF 

PROVIDER: S-EPMC8458476 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature