Metabolic drift in the aging nervous system is reflected in human cerebrospinal fluid.

ABSTRACT: Chronic diseases affecting the central nervous system (CNS) like Alzheimer's or Parkinson's disease typically develop with advanced chronological age. Yet, aging at the metabolic level has been explored only sporadically in humans using biofluids in close proximity to the CNS such as the cerebrospinal fluid (CSF). We have used an untargeted liquid chromatography high-resolution mass spectrometry (LC-HRMS) based metabolomics approach to measure the levels of metabolites in the CSF of non-neurological control subjects in the age of 20 up to 74. Using a random forest-based feature selection strategy, we extracted 69 features that were strongly related to age (p_age < 0.001, r_age = 0.762, R²_{Boruta age} = 0.764). Combining an in-house library of known s

SUBMITTER: Peters K 

PROVIDER: S-EPMC8458502 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature