FAM89A and IFI44L for distinguishing between viral and bacterial infections in children with febrile illness.

ABSTRACT:

Importance

The current lack of reliable rapid tests for distinguishing between bacterial and viral infections has contributed to antibiotic misuse.

Objective

This study aimed to develop a novel biomarker assay that integrates FAM89A and IFI44L measurements to assist in differentiating between bacterial and viral infections.

Methods

This prospective study recruited children with febrile illness from two hospitals between July 1, 2018, and June 30, 2019. A panel of three experienced pediatricians performed reference standard diagnoses of all patients (i.e., bacterial or viral infection) using available clinical and laboratory data, including a 28-day follow-up assessment. Assay operators were blinded to the reference standard diagnoses. The expression leve

SUBMITTER: Tian S 

PROVIDER: S-EPMC8458721 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature