<i>FAAH</i> and <i>CNR1</i> Polymorphisms in the Endocannabinoid System and Alcohol-Related Sleep Quality.

ABSTRACT: Sleep disturbances are common among individuals with alcohol use disorder (AUD) and may not resolve completely with short-term abstinence from alcohol, potentially contributing to relapse to drinking. The endocannabinoid system (ECS) is associated with both sleep and alcohol consumption, and genetic variation in the ECS may underlie sleep-related phenotypes among individuals with AUD. In this study, we explored the influence of genetic variants in the ECS (Cannabinoid receptor 1/CNR1: rs806368, rs1049353, rs6454674, rs2180619, and Fatty Acid Amide Hydrolase/FAAH rs324420) on sleep quality in individuals with AUD (N = 497) and controls without AUD (N = 389). We assessed subjective sleep quality (from the Pittsburgh Sleep Quality Index/PSQI) for both groups at bas

SUBMITTER: Soundararajan S 

PROVIDER: S-EPMC8458733 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature