Persistent High Percentage of HLA-DR⁺CD38^high CD8⁺ T Cells Associated With Immune Disorder and Disease Severity of COVID-19.

ABSTRACT:

Background

The global outbreak of coronavirus disease 2019 (COVID-19) has turned into a worldwide public health crisis and caused more than 100,000,000 severe cases. Progressive lymphopenia, especially in T cells, was a prominent clinical feature of severe COVID-19. Activated HLA-DR⁺CD38⁺ CD8⁺ T cells were enriched over a prolonged period from the lymphopenia patients who died from Ebola and influenza infection and in severe patients infected with SARS-CoV-2. However, the CD38⁺HLA-DR⁺ CD8⁺ T population was reported to play contradictory roles in SARS-CoV-2 infection.

Methods

A total of 42 COVID-19 patients, including 32 mild or moderate and 10 severe or critical cases, who received care at Beijing Ditan Hospit

SUBMITTER: Du J 

PROVIDER: S-EPMC8458852 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature