Effect of Basal Metabolic Rate on Cancer: A Mendelian Randomization Study.

ABSTRACT: Background: Basal metabolic rate is associated with cancer, but these observations are open to confounding. Limited evidence from Mendelian randomization studies exists, with inconclusive results. Moreover, whether basal metabolic rate has a similar role in cancer for men and women independent of insulin-like growth factor 1 increasing cancer risk has not been investigated. Methods: We conducted a two-sample Mendelian randomization study using summary data from the UK Biobank to estimate the causal effect of basal metabolic rate on cancer. Overall and sex-specific analysis and multiple sensitivity analyses were performed including multivariable Mendelian randomization to control for insulin-like growth factor 1. Results: We obtained 782 genetic variants strongly (p<

SUBMITTER: Ng JCM 

PROVIDER: S-EPMC8458883 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature