PRDM16, LRP1 and TRPM8 genetic polymorphisms are risk factor for Pakistani migraine patients.

ABSTRACT:

Background

Migraine is a chronic neurovascular condition characterized by recurring attacks of pulsating headaches. Genome-wide association studies (GWAS) identified many potential loci associated with migraine. To check the association of polymorphisms of PRDM16 (rs2651899), LRP1 (rs11172113), and TRPM8 (rs10166942) with migraine, the first time a case-control study was conducted in understudied Pakistani population.

Methods

The study included 127 migraine patients (21 in migraine with aura and 106 with migraine without aura group) and 120 healthy control subjects from different areas of Punjab, Pakistan. Blood samples were collected from all the participants, and DNA was isolated from the lymphocytes by the modified organic method. Sanger's sequencing

SUBMITTER: Zafar R 

PROVIDER: S-EPMC8459056 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature