Genomewide alteration of histone H3K4 methylation underlies genetic vulnerability to psychopathology.

ABSTRACT: Dysregulated histone methylation has emerged as a recurring theme in multiple neuropsychiatric disorders. However, it is yet unclear whether the altered histone methylation is associated with aetiologic mechanisms or an outcome of disease manifestation. In this study, we examined the genomewide association studies datasets of three major psychiatric disorders, schizophrenia (SCZ), bipolar disorder (BIP), and major depression disorder (MDD), which represents a total of 231,783 cases and 425,444 controls, to clarify the relationship. Our gene-set enrichment analysis results identified statistically significant association of genes involved in three histone methylation biological processes with the three adult-onset psychiatric disorders, which is mainly driven by the histone H3K4 methylation

SUBMITTER: Nesbit N 

PROVIDER: S-EPMC8459212 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature