Skin microvascular function and renal hemodynamics in overweight patients with type 2 diabetes: A cross-sectional study.

ABSTRACT:

Objective

Diabetic kidney disease is a microvascular complication of diabetes. Here, we assessed the association between skin microvascular function and renal hemodynamic function in a cohort of well-phenotyped adults with type 2 diabetes (T2D).

Methods

We included 81 overweight/obese adults (age: 62 ± 8 years; BMI: 32 ± 4 kg/m² ) with well-controlled T2D and no renal impairment. Skin microvascular function was assessed by nailfold capillary density in rest and after arterial occlusion (ie, peak capillary density). Renal hemodynamic functions (ie, measured glomerular filtration rate [mGFR], effective renal blood flow [ERBF], filtration fraction [FF], and effective renal vascular resistance [ERVR]) were assessed by combined inulin and para-aminohippurate clearances

SUBMITTER: Bouman EJ 

PROVIDER: S-EPMC8459253 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature