Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.
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ABSTRACT:
SUBMITTER: Boer CG
PROVIDER: S-EPMC8459317 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.
Boer Cindy G CG Hatzikotoulas Konstantinos K Southam Lorraine L Stefánsdóttir Lilja L Zhang Yanfei Y Coutinho de Almeida Rodrigo R Wu Tian T TT Zheng Jie J Hartley April A Teder-Laving Maris M Skogholt Anne Heidi AH Terao Chikashi C Zengini Eleni E Alexiadis George G Barysenka Andrei A Bjornsdottir Gyda G Gabrielsen Maiken E ME Gilly Arthur A Ingvarsson Thorvaldur T Johnsen Marianne B MB Jonsson Helgi H Kloppenburg Margreet M Luetge Almut A Lund Sigrun H SH Mägi Reedik R Mangino Massimo M Nelissen Rob R G H H RRGHH Shivakumar Manu M Steinberg Julia J Takuwa Hiroshi H Thomas Laurent F LF Tuerlings Margo M Babis George C GC Cheung Jason Pui Yin JPY Kang Jae Hee JH Kraft Peter P Lietman Steven A SA Samartzis Dino D Slagboom P Eline PE Stefansson Kari K Thorsteinsdottir Unnur U Tobias Jonathan H JH Uitterlinden André G AG Winsvold Bendik B Zwart John-Anker JA Davey Smith George G Sham Pak Chung PC Thorleifsson Gudmar G Gaunt Tom R TR Morris Andrew P AP Valdes Ana M AM Tsezou Aspasia A Cheah Kathryn S E KSE Ikegawa Shiro S Hveem Kristian K Esko Tõnu T Wilkinson J Mark JM Meulenbelt Ingrid I Lee Ming Ta Michael MTM van Meurs Joyce B J JBJ Styrkársdóttir Unnur U Zeggini Eleftheria E
Cell 20210826 18
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before. We report thumb and spine osteoarthritis risk variants and identify differences in genetic effects between weight-bearing and non-weight-bearing joints. We identify se ...[more]
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