A synthetic gene drive system for local, reversible modification and suppression of insect populations.

ABSTRACT: Replacement of wild insect populations with genetically modified individuals unable to transmit disease provides a self-perpetuating method of disease prevention but requires a gene drive mechanism to spread these traits to high frequency. Drive mechanisms requiring that transgenes exceed a threshold frequency in order to spread are attractive because they bring about local but not global replacement, and transgenes can be eliminated through dilution of the population with wild-type individuals. These features are likely to be important in many social and regulatory contexts. Here we describe the first creation of a synthetic threshold-dependent gene drive system, designated maternal-effect lethal underdominance (UD(MEL)), in which two maternally expressed toxins, located on separate chrom

SUBMITTER: Akbari OS 

PROVIDER: S-EPMC8459379 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature