Open-label trial of a single-day induction onto buprenorphine extended-release injection for users of heroin and fentanyl.

ABSTRACT:

Background and objectives

Fentanyl and other highly potent synthetic opioids are the leading cause of opioid overdose deaths in the United States.

Methods

This study was an open-label, uncontrolled 12-week outpatient clinical trial to test the feasibility of a single-day induction onto extended-release buprenorphine (BXR) injection treatment for five adults (N = 5) with opioid use disorder using heroin-containing fentanyl. Participants were planned to receive three monthly BXR injections (300, 300, and 100 mg).

Results

After receiving 24 mg sublingual buprenorphine (SL-BUP), all five participants received the BXR 300 mg injection on the first day of induction. All five participants were retained for the full 3-month study period postinduction and received all three sc

SUBMITTER: Mariani JJ 

PROVIDER: S-EPMC8459386 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature