Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms.

ABSTRACT:

Background

Vitamin D status has been associated with the presence and severity of several premenstrual symptoms (PMSx) in some, but not all studies. Inconsistencies among findings may be explained by unaccounted genetic variation in the vitamin D receptor (VDR).

Objective

To determine whether associations between vitamin D status and individual PMSx are influenced by VDR genotype.

Methods

Seven hundred sixteen women aged 20-29 years old from the Toronto Nutrigenomics and Health study provided plasma samples and completed a questionnaire on the presence and severity of 15 common PMSx. Plasma 25-hydroxyvitamin D (25(OH)D) concentration was measured and participants were categorized into sufficient (≥ 50 nmol/L) and insufficient (< 50 nmol/L) vitamin D status groups. DNA

SUBMITTER: Jarosz AC 

PROVIDER: S-EPMC8459465 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature