Epigenome-wide association study detects a novel loci associated with central obesity in healthy subjects.

ABSTRACT:

Background and aims

Central obesity is a condition that poses a significant risk to global health and requires the employment of novel scientific methods for exploration. The objective of this study is to use DNA methylation analysis to detect DNA methylation loci linked to obesity phenotypes, i.e. waist circumference and waist-to-hip ratio adjusted for BMI.

Methods and results

Two-hundred and ten healthy European participants from the STANISLAS Family Study (SFS), comprising 73 nuclear families, were comprehensively assessed for methylation status using Illumina Infinium HumanMethylation450 BeadChip. An epigenome-wide association study was performed, which identified a CpG site cg16170243 located on chromosome 18q21.2 significantly associated with waist circumference, after

SUBMITTER: Xie T 

PROVIDER: S-EPMC8459469 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature