FGFR2 alteration as a potential therapeutic target in poorly cohesive gastric carcinoma.

ABSTRACT:

Background

Poorly cohesive (PC) is a unique histologic subtype of gastric cancer (GC), with an increasing incidence in recent years. However, the molecular characteristics and therapeutic targets of PC GC are not yet well studied and there are no effective therapies for these patients.

Methods

Formalin fixed paraffin embedded (FFPE) samples of 556 GC patients, including 64 PC GC, were collected for next-generation sequencing (NGS). Clinical characteristics and genomic profiling were analyzed. FGFR2 expression was detected by quantitative real time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC). FGFR2 inhibitors response was studied in vitro.

Results

Among 556 GC patients, PC GC patients were younger (P = 0.004), had lower tumor mutation burden (TMB

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8459493 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature