Development and Verification of a Prostate Cancer Prognostic Signature Based on an Immunogenomic Landscape Analysis.

ABSTRACT:

Purpose

Prostate cancer (PCa) has a high incidence among older men. Until now, there are no immunological markers available to predict PCa patients' survival. Therefore, it is necessary to explore the immunological characteristics of PCa.

Methods

First, we retrieved RNA-seq and clinical data of 499 PCa and 52 normal prostate tissue samples from the Cancer Genome Atlas (TCGA). We identified 193 differentially expressed immune-related genes (IRGs) between PCa and normal prostate tissues. Functional enrichment analyses showed that the immune system can participate in PCa initiation. Then, we constructed a correlation network between transcription factors (TFs) and IRGs. We performed univariate and multivariate Cox regression analyses and identified five key prognostic IRGs (S10

SUBMITTER: Cheng H 

PROVIDER: S-EPMC8459614 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature