Sharpened and Mechanically Durable Carbon Fiber Electrode Arrays for Neural Recording.

ABSTRACT: Bioelectric medicine treatments target disorders of the nervous system unresponsive to pharmacological methods. While current stimulation paradigms effectively treat many disorders, the underlying mechanisms are relatively unknown, and current neuroscience recording electrodes are often limited in their specificity to gross averages across many neurons or axons. Here, we develop a novel, durable carbon fiber electrode array adaptable to many neural structures for precise neural recording. Carbon fibers ( [Formula: see text] diameter) were sharpened using a reproducible blowtorchmethod that uses the reflection of fibers against the surface of a water bath. The arrays were developed by partially embedding carbon fibers in medical-grade silicone to improve durability. We recorded acute sponta

SUBMITTER: Welle EJ 

PROVIDER: S-EPMC8459724 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature