SigV Mediates Lysozyme Resistance in Enterococcus faecalis via RsiV and PgdA.

ABSTRACT: Enterococcus faecalis is a gut commensal but transitions to a pathogenic state as a consequence of intestinal dysbiosis and/or the presence of indwelling medical devices, causing a wide range of infections. One of the unique features of E. faecalis is its ability to display high level resistance to lysozyme, an important host defense of the innate immune response. Lysozyme resistance in E. faecalis is known to be mediated by the extracytoplasmic function (ECF) sigma factor SigV. PgdA and RsiV expression is directly regulated by SigV, but pgdA and rsiV mutants display nominal changes in lysozyme resistance, suggesting that additional gene products in the SigV regulon contribute to lysozyme resistance. Using transcriptome sequencing (RNA-seq) analysis, we c

SUBMITTER: Parthasarathy S 

PROVIDER: S-EPMC8459761 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature