Arjunetin as a promising drug candidate against SARS-CoV-2: molecular dynamics simulation studies.

ABSTRACT: Stem and bark of the tree Terminalia arjuna Wight & Arn. (Combretaceae) has been documented to exhibit therapeutic properties like cardiotonic, anticancer, antiviral, antibacterial, antifungal, hypercholesterolemia, hypolipidemic, and anti-coagulant. Our previous studies have shown that, ethanolic extract of T. arjuna bark exhibits radical scavenging anti-oxidant activity and also effectively inhibited catalase activity. In this study, oleanane triterpenoids type compounds viz., oleanolic acid, arjunolic acid, arjunolitin, arjunetin were isolated from ethanolic bark extract as bio-active compound and their structures were elucidated using ¹H, ¹³C NMR, HR-ESIMS, IR. Of the various compounds, Arjunetin showed significant inhibition of catalase activ

SUBMITTER: Arumugam GS 

PROVIDER: S-EPMC8459932 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature