Automated Thrombin Generation Assay for Rivaroxaban, Apixaban, and Edoxaban Measurements.

ABSTRACT: Background: The thrombin generation assay (TG) is a promising approach to measure the degree of anticoagulation in patients treated with direct oral anticoagulants (DOAC). A strong association with plasma drug concentrations would be a meaningful argument for the potential use to monitor DOAC. Objectives: We aimed to study the correlation of TG with rivaroxaban, apixaban, and edoxaban drug concentrations in a large, prospective multicenter cross-sectional study. Methods: Five-hundred and fifty-nine patients were included in nine tertiary hospitals. The Technothrombin® TG was conducted in addition to an anti-Xa assay; LC-MS/MS was performed as the reference standard. Results: Correlation (r_s) between thrombin generation measurements and drug concentrat

SUBMITTER: Meihandoest T 

PROVIDER: S-EPMC8459937 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature