Pore Forming Protein Induced Biomembrane Reorganization and Dynamics: A Focused Review.

ABSTRACT: Pore forming proteins are a broad class of pathogenic proteins secreted by organisms as virulence factors due to their ability to form pores on the target cell membrane. Bacterial pore forming toxins (PFTs) belong to a subclass of pore forming proteins widely implicated in bacterial infections. Although the action of PFTs on target cells have been widely investigated, the underlying membrane response of lipids during membrane binding and pore formation has received less attention. With the advent of superresolution microscopy as well as the ability to carry out molecular dynamics (MD) simulations of the large protein membrane assemblies, novel microscopic insights on the pore forming mechanism have emerged over the last decade. In this review, we focus primarily on results collated in our

SUBMITTER: Ilangumaran Ponmalar I 

PROVIDER: S-EPMC8459938 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature