Modelling to explore the potential impact of asymptomatic human infections on transmission and dynamics of African sleeping sickness.

ABSTRACT: Gambiense human African trypanosomiasis (gHAT, sleeping sickness) is one of several neglected tropical diseases (NTDs) where there is evidence of asymptomatic human infection but there is uncertainty of the role it plays in transmission and maintenance. To explore possible consequences of asymptomatic infections, particularly in the context of elimination of transmission-a goal set to be achieved by 2030-we propose a novel dynamic transmission model to account for the asymptomatic population. This extends an established framework, basing infection progression on a number of experimental and observation gHAT studies. Asymptomatic gHAT infections include those in people with blood-dwelling trypanosomes, but no discernible symptoms, or those with parasites only detectable in skin. Given curre

SUBMITTER: Aliee M 

PROVIDER: S-EPMC8459990 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature