Combined Scutellarin and C₁₈H₁₇NO₆ Imperils the Survival of Glioma: Partly Associated With the Repression of PSEN1/PI3K-AKT Signaling Axis.

ABSTRACT: Glioma, the most common intracranial tumor, harbors great harm. Since the treatment for it has reached the bottleneck stage, the development of new drugs becomes a trend. Therefore, we focus on the effect of scutellarin (SCU) and its combination with C₁₈H₁₇NO₆ (abbreviated as combination) on glioma and its possible mechanism in this study. Firstly, SCU and C₁₈H₁₇NO₆ both suppressed the proliferation of U251 and LN229 cells in a dose-dependent manner, and C₁₈H₁₇NO₆ augmented the inhibition effect of SCU on U251 and LN229 cells in vitro. Moreover, there was an interactive effect between them. Secondly, SCU and C₁₈H₁₇NO₆ decreased U251 cells in G2 p

SUBMITTER: He XY 

PROVIDER: S-EPMC8460401 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature