Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children's Study.

ABSTRACT:

Background

The association between fetal exposure to alcohol and congenital structural disorders remains inconclusive. The present study searched for relationships between maternal alcohol consumption during pregnancy and the risk of congenital malformations.

Methods

We evaluated the fixed dataset of a large national birth cohort study including 73,595 mothers with a singleton live birth. Information regarding the alcohol consumption of mothers was obtained from self-reported questionnaires. Physicians assessed for 6 major congenital malformations (congenital heart defects [CHDs], male genital abnormalities, limb defects, cleft lip and/or cleft palate [orofacial clefts (OFC)], severe brain abnormalities, and gastrointestinal obstructions) up to 1 month after birth. Multiple

SUBMITTER: Kurita H 

PROVIDER: S-EPMC8460444 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature