Metastasis prognostic factors and cancer stem cell-related transcription factors associated with metastasis induction in canine metastatic mammary gland tumors.

ABSTRACT:

Background

Canine mammary gland tumor (MGT) is the most common cancer in aged female dogs. Although it's important to identify reliable metastasis or prognostic factors by evaluating related to cell division, adhesion, and cancer stem cell-related transcription factor (TF) in metastasis-induced canine MGT, but there are limited studies.

Objectives

We aimed to identify metastasis prognostic factors and cancer stem cell-TFs in canine MGTs.

Methods

Age-matched female dogs diagnosed with MGT only were classified into metastatic and non-metastatic groups by histopathological staining of MGT tissues. The mRNA levels of cancer prognostic metastasis molecular factors (E-cadherin, ICAM-1, PRR14, VEGF, HPRT1, RPL4 and hnRNP H) an

SUBMITTER: Kim S 

PROVIDER: S-EPMC8460459 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature